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7-Acylaminocephalosporanic acid derivatives

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专利名称:7-Acylaminocephalosporanic acid derivatives发明人:Takao Takaya,Hisashi Takasugi,Masayoshi

Murata,Akiteru Yoshioka

申请号:US06/336161申请日:19811231公开号:US04438113A公开日:19840320

摘要:This invention relates to novel 7-acylaminocephalosporanic acid derivatives andpharmaceutically acceptable salts thereof, of high antimicrobial activity, said novelderivatives having the formula ##STR1## wherein R.sup.1 is amino or protected amino,

R. sup.2 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkenyl,protected carboxy(lower)alkenyl, or lower unsaturated aliphatic hydrocarbon,

R.sup.3 is hydrogen, halogen, methyl, lower alkoxy, lower alkylthiomethyl, loweralkanoyloxymethyl or a heterocyclicthiomethyl which may have suitable substituents(s),

R.sup.4 is carboxy or protected carboxy,

R.sup.5 is hydrogen or lower alkyl, and

< P>X is halogen,

provided that when R.sup.3 is lower alkanoyloxymethyl, then R.sup.2 is lowerunsaturated aliphatic hydrocarbon, and pharmaceutically acceptable salts thereof.

申请人:FUJISAWA PHARMACEUTICAL CO., LTD.

代理机构:Oblon, Fisher, Spivak, McClelland & Maier

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